Efficiency Wage Hypothesis—The Case of Pakistan

The object of this paper is to present an exposition of Efficiency Wage theory, and to test its basic assertions in the context of Pakistan. The Great Depression of 1929 showed that labour disequilibrium persists for long periods of time. One of the causes of this was rigidity of nominal wages, which was assumed without explanation by Keynes in his General Theory. Stagflation in the 1970s led to re-examination of Keynesian theories and a search for a satisfactory theoretical explanation of wage rigidity. Efficiency Wage theories provide an explanation by suggesting that worker productivity increases with wage. This means that firms may not have incentive to cut wages even when they are above equilibrium. Substantial empirical evidence for efficiency wages has been found in the context of advanced economies, but there is very little literature for developingcountries. Saygili (1998) has given evidence for efficiency wages in the Turkish economy. Nasir (2000) provides empirical evidence for a wage differential between private and public sectors in Pakistan, which conforms to efficiency wage considerations. In this paper, we show that the textile sector in Pakistan appears to offer efficiency wages, while other sectors conform to neoclassical competitive labour market theorie

Pathway Hunter Tool (PHT) � A Platform for Metabolic Network Analysis and Potential Drug Targeting

Metabolic network analysis will play a major role in �Systems Biology� in the future as they represent the backbone of molecular activity within the cell. Recent studies have taken a comparative approach toward interpreting these networks, contrasting networks of different species and molecular types, and under varying conditions. We have developed a robust algorithm to calculate shortest path in the metabolic network using metabolite chemical structure information. A divide and conquer technique using Maximal Common Subgraph (MCS) approach and binary fingerprint was used to map each substrate onto its corresponding product. Then for the calculation of the shortest paths (using modified Breadth First Search algorithm) the two biochemical criteria �local� and �global� structural similarity were used, where �local similarity� is defined as the similarity between two intermediate molecules and �global similarity� is defined as the amount of conserved structure found between the source metabolite and the destination metabolites after a series of reaction steps. The pathway alignment was introduced to find enzyme(s) preference in the pathway of various organisms (a local and global outlook to metabolic networks). This was also used to predict potentially missing enzymes in the pathway. A novel concept called �load points� and �choke points� identifies hot spots in the network. This was used to find important enzymes in the pathogens metabolic network for potential drug targets

Design of Novel Molecular Micelles for Capillary Electrophoresis

The research presented in this dissertation involves the synthesis, characterization, and application of novel anionic and cationic chiral molecular micelles in capillary electrophoresis (CE) for the separation of diverse chiral compounds. Chapter 1 presents brief overview of the surfactants, micelle polymer, CE and micellar electrokinetic chromatography (MEKC). Chapter 2 describes the simultaneous enantioseparation of eight single chiral center â-blockers using two novel leucine and isoleucine based polymeric surfactants. The simultaneous enantioseparation of multichiral center bearing â-blockers, nadolol and labetalol is described in chapter 3. A synergistic approach, using a combination of polysodium N-undecenoxycarbonyl-L-isoleucinate (poly-L-SUCIL) and sulfated â-CD showed dramatic enantioseparation of four stereoisomers of nadolol. On the other hand for labetalol, enantiomeric separation remains unaffected using the dual chiral selector system. Chapter 4 deals with the enantiomeric separation of the binaphthyl derivatives that was found to be influenced by pH, type and concentration of the background electrolyte as well as concentration of the polymeric surfactant. In chapter 5, characterization of five alkenoxy leucine-based surfactants with variations in chain length (C8-C11), polymerization concentration and degree of polymerization showed significant effects on the chiral resolution and efficiency of hydrophobic â-blockers. The synthesis and characterization of two positively charged amino acid derived chiral ionic liquids (ILs) and their corresponding polymers is presented in chapter 6. Chiral separation of two acidic analyte (difficult to resolve with anionic micelles) can be achieved with both monomers and polymers of ILs. In chapter 7, the synthesis and detailed characterization of three pH independent amino acids derived (L-leucinol, L-isoleucinol and L-valinol) sulfated chiral polymeric surfactants is presented. These chiral sulfated surfactants are thoroughly characterized and the morphological behavior of polymeric sulfated surfactants is revealed using cryogenic high-resolution electron microscopy. The work clearly demonstrates for the first time the superiority of chiral separation in MEKC coupled to mass spectrometry at low pH. Finally, in chapter 8, six amino acid derived chiral surfactants with carboxylate and sulfate head groups were compared for enantioseparation of broad range of structurally diverse racemic compounds at neutral and basic pH conditions

Fungal osteomyelitis in a patient with chronic granulomatous disease: Case report and review of the literature

Chronic granulomatous disease (CGD) is the most common of the primary immunodeficiency in children. It is caused by single gene defect resulting in dysfunctional nicotinamide adenine dineucleotide phosphate (NADPH) oxidase complex causing recurrent bacterial and fungal infections. Here we present the case of a 9 year old boy who was a known case of CGD since three years of age. He presented with recent history of fever, left sided pain in the scapular region and difficulty in breathing. Chest imaging revealed developing left upper lobe consolidation and erosion of the 3rd posterior rib. The child underwent video assisted thoracoscopic surgery (VATS) and biopsy of the lesion. Histopathology revealed fungal hyphae which were confirmed to be Aspergillus nidulans on staining. He was successfully treated with voriconazole therapy. We will also review the literature on fungal osteomyelitis in CGD patients

Efficiency Wage Hypothesis—The Case of Pakistan

The goal of this section is to point out the observed difficulties with the classical/neoclassical theory of labour markets. According to classical and neoclassical economics, the labour market is a market like any other market. The equilibrium wage is determined by the intersection of the supply and demand for labour

The social construction of Muslim minority groups in Canada

This dissertation explores Canadian mainstream print media's discourse on Muslim minority groups in Canada in the pre- and post-9/11 timeframe. By using critical discourse analysis (CDA) of three Canadian English newspapers as well as focus group discussions, and individual interviews, this study explores the issues of racialization, Islamophobia, and the role of Canadian mainstream print media in the construction of stereotypical images of the Muslim minority groups in Canada. The data reveal the frequent usage of stereotypical racialized terms in three Canadian newspapers (two national and one local) directed toward Muslims in the post-9/11 period cultivated moral panics in Canadian society. Although Muslim were negatively portrayed in these newspapers before 9/11, the situation escalated in the post-9/11 era. Participants in the focus group discussion and individual interviews also stated that the post-9/11 moral panics augmented and perpetuated the negative feelings towards Muslims. An increased trend in racial and religious discrimination against Muslims was observed throughout Canada after the 9/11 incident in New York. The negative portrayal of Muslims stemmed from a lack of understanding of Muslim minority groups, their culture and/or international distortion of Muslims by media personnel, who did not differentiate between the small number of Muslims who engaged in or support terrorist acts, and the majority of Muslims who do not. By neglecting to recognize this conflation of the different perspectives of Muslims on these matters, the selected newspapers contributed to the escalation of moral panics in Canadian society, which resulted in increased negative attitudes towards Muslims

Virtual Runtime Application Partitions for Resource Management in Massively Parallel Architectures

This thesis presents a novel design paradigm, called Virtual Runtime Application Partitions (VRAP), to judiciously utilize the on-chip resources. As the dark silicon era approaches, where the power considerations will allow only a fraction chip to be powered on, judicious resource management will become a key consideration in future designs. Most of the works on resource management treat only the physical components (i.e. computation, communication, and memory blocks) as resources and manipulate the component to application mapping to optimize various parameters (e.g. energy efficiency). To further enhance the optimization potential, in addition to the physical resources we propose to manipulate abstract resources (i.e. voltage/frequency operating point, the fault-tolerance strength, the degree of parallelism, and the configuration architecture). The proposed framework (i.e. VRAP) encapsulates methods, algorithms, and hardware blocks to provide each application with the abstract resources tailored to its needs. To test the efficacy of this concept, we have developed three distinct self adaptive environments: (i) Private Operating Environment (POE), (ii) Private Reliability Environment (PRE), and (iii) Private Configuration Environment (PCE) that collectively ensure that each application meets its deadlines using minimal platform resources. In this work several novel architectural enhancements, algorithms and policies are presented to realize the virtual runtime application partitions efficiently. Considering the future design trends, we have chosen Coarse Grained Reconfigurable Architectures (CGRAs) and Network on Chips (NoCs) to test the feasibility of our approach. Specifically, we have chosen Dynamically Reconfigurable Resource Array (DRRA) and McNoC as the representative CGRA and NoC platforms. The proposed techniques are compared and evaluated using a variety of quantitative experiments. Synthesis and simulation results demonstrate VRAP significantly enhances the energy and power efficiency compared to state of the art.Siirretty Doriast